Go read John Snow's Grant application and the NIH reviews.
Project Title: An Investigation into the Mode of Communication of Cholera
DESCRIPTION (provided by applicant):The cholera has wreaked intermittent misfortune and death upon large swaths of civilization. While its reach extends ever farther, engulfing new port cities and populations, we have come no closer to fathoming the mode of its communication nor to stopping this awful malady. The disease affects the alimentary tract first and foremost, which implies strongly that one should look to contaminated water or food to explain its transmission. Its epidemic spread is along the pathways of human commerce, but it spreads no faster than people travel. As it usually appears first at seaports, it would appear to be spread by mariners, but it only affects mariners sailing from cholera-affected ports. There are numerous examples of the cholera apparently being transmitted by consumption of water polluted by excreta. Nonetheless, the hypothesis that cholera travels through humans and especially through contaminated water has not been put to crucial scientific examination. Herein, the PI proposes to conduct that crucial study.The Panel was having none of it
We believe that the proposal would have been stronger if the PI had forged some institutional ties, or had proposed to collaborate with the local sanitarian community and to integrate this project into a broader effort to study and control cholera. His lack of experience doing this type of research, his self-employment as a general practitioner of medicine with a practice largely devoted to administering anesthesia, his coolness for collaborating with the broader London medical community, and his single-minded attitude toward other currently debated scientific theories, all underscore our concern about the research environment and the likelihood that the PI can successfully conduct this work as proposed.Moar, much moar at the link, but if a bunny is hopping about London looking at the sites a visit to the pump handle is worthwhile if only to say you were there and the pub opposite is not bad